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The Rat Genome Database pathway portal. Database (Oxford) 2011;2011:bar010 PMID: 21478484 PMCID: PMC3072770

Pubmed ID

21478484

DOI

10.1093/database/bar010

Abstract

The set of interacting molecules collectively referred to as a pathway or network represents a fundamental structural unit, the building block of the larger, highly integrated networks of biological systems. The scientific community's interest in understanding the fine details of how pathways work, communicate with each other and synergize, and how alterations in one or several pathways may converge into a disease phenotype, places heightened demands on pathway data and information providers. To meet such demands, the Rat Genome Database [(RGD) http://rgd.mcw.edu] has adopted a multitiered approach to pathway data acquisition and presentation. Resources and tools are continuously added or expanded to offer more comprehensive pathway data sets as well as enhanced pathway data manipulation, exploration and visualization capabilities. At RGD, users can easily identify genes in pathways, see how pathways relate to each other and visualize pathways in a dynamic and integrated manner. They can access these and other components from several entry points and effortlessly navigate between them and they can download the data of interest. The Pathway Portal resources at RGD are presented, and future directions are discussed. Database URL: http://rgd.mcw.edu.

Author List

Petri V, Shimoyama M, Hayman GT, Smith JR, Tutaj M, de Pons J, Dwinell MR, Munzenmaier DH, Twigger SN, Jacob HJ, RGD Team

Authors

Melinda R. Dwinell PhD Center Associate Director, Associate Professor in the Physiology department at Medical College of Wisconsin
Mary E. Shimoyama PhD Associate Professor in the Biomedical Engineering department at Medical College of Wisconsin




Scopus

2-s2.0-80052334281   13 Citations

MESH terms used to index this publication - Major topics in bold

Animals
Databases, Genetic
Gene Regulatory Networks
Genome
Humans
Internet
Male
Molecular Sequence Annotation
Prostatic Neoplasms
Rats
Signal Transduction
jenkins-FCD Prod-332 f92a19b0ec5e8e1eff783fac390ec127e367c2b5