Faculty Collaboration Database

Rostral ventral medullary surface activity during hypercapnic challenges in awake and anesthetized goats. Neurosci Lett 1995 Jun 09;192(2):89-92

Date

06/09/1995

Pubmed ID

7675328

DOI

10.1016/0304-3940(95)11620-c

Scopus ID

2-s2.0-0029007822 (requires institutional sign-in at Scopus site)   11 Citations

Abstract

Regions within the rostral ventral medullary surface (RVMS) play an important role in cardiorespiratory responses to CO2 during anesthesia. Activity within a RVMS area, in which local cooling elicited marked ventilatory and blood pressure reductions, was measured as 660 nm scattered light changes in 5 goats following 5% CO2 challenges during waking and anesthetic states. During wakefulness, hypercapnia elicited a substantial, short latency transient (1-1.5 min) activity increase, followed by a sustained decrease. Stimulus cessation elicited a large and rapid off-transient activity increase which persisted for approximately 20 min. In contrast, during halothane anesthesia, the initial activation was absent, and the later activity decline and off-response were much reduced. We conclude that biphasic RVMS activity responses emerge to CO2 stimulation, and are state-dependent.

Author List

Gozal D, Ohtake PJ, Rector DM, Lowry TF, Pan LG, Forster HV, Harper RM

Author

Hubert V. Forster PhD Professor in the Physiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Administration, Inhalation
Anesthesia
Animals
Blood Pressure
Carbon Dioxide
Female
Goats
Hypercapnia
Light
Medulla Oblongata
Optics and Photonics
Reaction Time
Respiration
Scattering, Radiation
Wakefulness