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Characterization and quantification of a pharyngo-UES contractile reflex in cats. Am J Physiol 1994 Dec;267(6 Pt 1):G972-83

Date

12/01/1994

Pubmed ID

7810665

DOI

10.1152/ajpgi.1994.267.6.G972

Scopus ID

2-s2.0-0028606182   50 Citations

Abstract

We characterized and quantified a reflex from the pharyngeal mucosa to the upper esophageal sphincter (UES). Seventeen cats were decerebrated, and the pharynx was exposed by opening the cricothyroid ligament. UES motor activity was assessed by recording electromyographic (EMG) activity from the pharyngeal constrictors, i.e., the thyropharyngeus (TP) and cricopharyngeus (CP). The pharyngeal mucosa was stimulated by touch or pressure. Both stimuli activated contraction of the CP primarily when applied to the naso-, laryngo-, or hypopharynx, but pressure was more effective. The anteromedial portion of the hypopharynx was the most sensitive zone, but there was no strong stimulus-response relationship. The reflex response to a 1-s stimulus occurred at a delay of 0.46 +/- 0.06 s and lasted 4.5 +/- 0.5 s. This pharyngo-UES reflex was blocked by anesthesia of the mucosa or transection of the glossopharyngeal or pharyngoesophageal nerves but not the vagus nerves. In contrast, the esophago-UES contractile reflex was not blocked by anesthesia of the pharyngeal mucosa or transection of the glossopharyngeal nerves but was blocked by transection of either the vagus or pharyngoesophageal nerves. We concluded that the pharyngo-UES contractile reflex was activated by pharyngeal mucosal mechanoreceptors whose afferent limb was the glossopharyngeal nerve and whose efferent limb was the pharyngoesophageal branch of the vagus nerve.

Author List

Medda BK, Lang IM, Layman R, Hogan WJ, Dodds WJ, Shaker R

Authors

Walter J. Hogan MD Professor in the Medicine department at Medical College of Wisconsin
Ivan M. Lang DVM, PhD Professor in the Medicine department at Medical College of Wisconsin
Bidyut K. Medda PhD Associate Professor in the Medicine department at Medical College of Wisconsin
Reza Shaker MD Assoc Provost, Sr Assoc Dean, Ctr Dir, Chief, Prof in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Cats
Deglutition
Esophagogastric Junction
Female
Glossopharyngeal Nerve
Male
Mechanoreceptors
Muscle Contraction
Pharynx
Reflex
Vagus Nerve
jenkins-FCD Prod-411 e00897e83867fcfa48419861683711f8d99adb75