Lateralized human brain language systems demonstrated by task subtraction functional magnetic resonance imaging. Arch Neurol 1995 Jun;52(6):593-601
Date
06/01/1995Pubmed ID
7763208DOI
10.1001/archneur.1995.00540300067015Scopus ID
2-s2.0-0029054076 (requires institutional sign-in at Scopus site) 319 CitationsAbstract
OBJECTIVE: To develop a procedure for noninvasive measurement of language lateralization with functional magnetic resonance imaging (MRI).
DESIGN: Functional neuroimaging using time-series echo-planar MRI.
SETTING: University medical center research facility.
SUBJECTS: Five healthy, right-handed, young adults.
MAIN OUTCOME MEASURES: Number of MRI voxels in left and right hemispheres showing task-related signal increases during two contrasting auditory processing tasks. The nonlinguistic task involved processing of pure tones, while the linguistic task involved processing of single words based on semantic content.
RESULTS: The pure-tone processing task activated temporal lobe auditory areas and dorsolateral frontal regions bilaterally. Using this task as a control condition, the semantic processing task resulted in lateralized activity in distributed regions of the left hemisphere. A significant effect of task on intrahemispheric activity pattern was demonstrated in every subject. Results were reproduced in preliminary studies of test-retest reliability.
CONCLUSIONS: The results demonstrate the lateralized anatomy of semantic linguistic systems in contrast to non-linguistic auditory sensory processors and introduce a task subtraction technique adapted for functional MRI as a noninvasive measure of language lateralization.
Author List
Binder JR, Rao SM, Hammeke TA, Frost JA, Bandettini PA, Jesmanowicz A, Hyde JSAuthor
Jeffrey R. Binder MD Professor in the Neurology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAuditory Perception
Brain
Brain Mapping
Cerebrovascular Circulation
Female
Functional Laterality
Humans
Language
Magnetic Resonance Imaging
Male
Psychomotor Performance
Subtraction Technique