Oxygen activation during the interaction between MPTP metabolites and synthetic neuromelanin--an ESR-spin trapping, optical, and oxidase electrode study. Biochem Biophys Res Commun 1988 Jul 29;154(2):781-8
Date
07/29/1988Pubmed ID
2840906DOI
10.1016/0006-291x(88)90208-2Scopus ID
2-s2.0-0023742708 (requires institutional sign-in at Scopus site) 11 CitationsAbstract
Oxidase electrode measurements as well as optical and electron spin resonance spectroscopic data have shown that synthetic neuromelanin oxidizes the neurotoxin metabolite 1-methyl-4-phenyl-2,3-dihydropyridinium in a dose-dependent manner forming 1-methyl-4-phenylpyridinium and hydrogen peroxide. Hydroxyl radicals are formed in this reaction which is promoted by iron chelates. In contrast, neither 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine nor 1-methyl-4-phenylpyridinium reacts with synthetic neuromelanin in a similar fashion. The mechanism of selective toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in pigmented neuronal cells is discussed in the light of these findings.
Author List
Korytowski W, Felix CC, Kalyanaraman BAuthor
Balaraman Kalyanaraman PhD Professor in the Biophysics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineDopamine
Electrodes
Electron Spin Resonance Spectroscopy
Hydroxides
Hydroxyl Radical
Melanins
Oxidoreductases
Oxygen
Pyridines
Pyridinium Compounds
