Mechanism of oxidation of 1-methyl-4-phenyl-2,3-dihydropyridinium (MPDP+). Biochem Biophys Res Commun 1987 Apr 29;144(2):692-8
Date
04/29/1987Pubmed ID
3579936DOI
10.1016/s0006-291x(87)80020-7Scopus ID
2-s2.0-0023229054 (requires institutional sign-in at Scopus site) 16 CitationsAbstract
Oxidase electrode measurements have shown that the neurotoxin metabolite 1-methyl-4-phenyl-2,3-dihydropyridinium autoxidizes to hydrogen peroxide and 1-methyl-4-phenylpyridinium in a reaction promoted by iron chelates. The mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity is discussed in the light of these findings.
Author List
Korytowski W, Felix CC, Kalyanaraman BAuthor
Balaraman Kalyanaraman PhD Professor in the Biophysics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
DeferoxamineHydrogen Peroxide
Kinetics
Oxidation-Reduction
Pyridinium Compounds
Spectrophotometry, Ultraviolet