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Mechanism of oxidation of 1-methyl-4-phenyl-2,3-dihydropyridinium (MPDP+). Biochem Biophys Res Commun 1987 Apr 29;144(2):692-8

Date

04/29/1987

Pubmed ID

3579936

DOI

10.1016/s0006-291x(87)80020-7

Scopus ID

2-s2.0-0023229054 (requires institutional sign-in at Scopus site)   16 Citations

Abstract

Oxidase electrode measurements have shown that the neurotoxin metabolite 1-methyl-4-phenyl-2,3-dihydropyridinium autoxidizes to hydrogen peroxide and 1-methyl-4-phenylpyridinium in a reaction promoted by iron chelates. The mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity is discussed in the light of these findings.

Author List

Korytowski W, Felix CC, Kalyanaraman B

Author

Balaraman Kalyanaraman PhD Professor in the Biophysics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Deferoxamine
Hydrogen Peroxide
Kinetics
Oxidation-Reduction
Pyridinium Compounds
Spectrophotometry, Ultraviolet