Noxious distention of viscera results in differential c-Fos expression in second order sensory neurons receiving 'sympathetic' or 'parasympathetic' input. Neurosci Lett 1994 Oct 10;180(1):71-5
Date
10/10/1994Pubmed ID
7877766DOI
10.1016/0304-3940(94)90916-4Scopus ID
2-s2.0-0027960175 (requires institutional sign-in at Scopus site) 36 CitationsAbstract
Visceral organs receive dual innervation from primary afferents commonly referred to as 'sympathetic' and 'parasympathetic' afferents. We have previously reported a significantly greater induction of immediate-early genes in the viscerotopically appropriate spinal cord segments receiving 'parasympathetic' afferent innervation (pelvic nerve) compared with those receiving 'sympathetic' afferent innervation (hypogastric nerve) following noxious colorectal distention. In this study, the nucleus of the solitary tract (NTS) and viscerotopically appropriate spinal cord segments were labeled immunocytochemically for c-Fos following noxious gastric or esophageal distention to determine if the differential labeling following 'sympathetic' (spinal) and 'parasympathetic' (vagal) visceral afferent input is a general phenomenon of the gastrointestinal tract. Gastric distention and esophageal distention induced considerable c-Fos in the NTS and virtually none in the thoracic spinal segments. These data suggest that 'parasympathetic' visceral afferents may be different than 'sympathetic' visceral afferents with respect to their ability to induce c-Fos following noxious visceral distention.
Author List
Traub RJ, Lim F, Sengupta JN, Meller ST, Gebhart GFAuthor
Jyoti N. Sengupta PhD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAutonomic Pathways
Digestive System
Digestive System Physiological Phenomena
Gene Expression
Genes, fos
Male
Neurons, Afferent
Parasympathetic Nervous System
Physical Stimulation
Rats
Rats, Sprague-Dawley
Solitary Nucleus
Spinal Cord
Sympathetic Nervous System
