Potential therapeutic benefits of strategies directed to mitochondria. Antioxid Redox Signal 2010 Aug 01;13(3):279-347
Date
12/17/2009Pubmed ID
20001744Pubmed Central ID
PMC2936955DOI
10.1089/ars.2009.2788Scopus ID
2-s2.0-77954113727 (requires institutional sign-in at Scopus site) 154 CitationsAbstract
The mitochondrion is the most important organelle in determining continued cell survival and cell death. Mitochondrial dysfunction leads to many human maladies, including cardiovascular diseases, neurodegenerative disease, and cancer. These mitochondria-related pathologies range from early infancy to senescence. The central premise of this review is that if mitochondrial abnormalities contribute to the pathological state, alleviating the mitochondrial dysfunction would contribute to attenuating the severity or progression of the disease. Therefore, this review will examine the role of mitochondria in the etiology and progression of several diseases and explore potential therapeutic benefits of targeting mitochondria in mitigating the disease processes. Indeed, recent advances in mitochondrial biology have led to selective targeting of drugs designed to modulate and manipulate mitochondrial function and genomics for therapeutic benefit. These approaches to treat mitochondrial dysfunction rationally could lead to selective protection of cells in different tissues and various disease states. However, most of these approaches are in their infancy.
Author List
Camara AK, Lesnefsky EJ, Stowe DFAuthors
Amadou K. Camara PhD Professor in the Anesthesiology department at Medical College of WisconsinDavid F. Stowe MD, PhD Professor in the Anesthesiology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AgingAnimals
Antioxidants
DNA, Mitochondrial
Disease
Drug Design
Electron Transport
Humans
Life Expectancy
Mitochondria
Mitochondrial Proteins
Oxidative Phosphorylation
Reactive Nitrogen Species
Reactive Oxygen Species
