Increased C-kit intensity is a poor prognostic factor for progression-free and overall survival in patients with newly diagnosed AML. Leuk Res 2008 Jun;32(6):913-8
Date
10/12/2007Pubmed ID
17928050DOI
10.1016/j.leukres.2007.08.019Scopus ID
2-s2.0-40749132899 (requires institutional sign-in at Scopus site) 31 CitationsAbstract
C-kit, a tyrosine kinase receptor, is expressed on most myeloid blasts and is thought to be important in the pathogenesis of AML. Activation of the c-kit receptor leads to phosphorylation and activation of downstream signaling proteins, which are important for cell survival and proliferation. Here, we discuss the prognostic impact of c-kit intensity, measured using the mean fluorescent index (MFI) in patients with newly diagnosed AML. On multivariate analysis, c-kit MFI>20.3 correlated with a decreased progression-free survival and overall survival, independent of known prognostic factors (age, white blood count at diagnosis and cytogenetics). Whether inhibiting c-kit in patients with AML will alter prognosis is the basis of ongoing clinical trials.
Author List
Advani AS, Rodriguez C, Jin T, Jawde RA, Saber W, Baz R, Kalaycio M, Sobecks R, Sekeres M, Tripp B, Hsi EAuthor
Wael Saber MD, MS Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Aged
Disease Progression
Disease-Free Survival
Female
Flow Cytometry
Fluorescence
Humans
Leukemia, Myeloid, Acute
Male
Middle Aged
Proto-Oncogene Proteins c-kit
Retrospective Studies
Survival Rate
