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Antibody responses to Onchocerca volvulus in Ecuadorian Indians and blacks. Trop Med Parasitol 1993 Sep;44(3):152-4

Date

09/01/1993

Pubmed ID

8256087

Abstract

In Ecuador, previous epidemiological studies of onchocerciasis affecting a population consisting of Blacks of African origin and Amerindians of the Chachi tribe, have demonstrated different frequencies of clinical disease manifestations in each racial group. To explore the possibility of differential antibody responses to O. volvulus antigens in this population, a subset of sera from these two groups of Ecuadorians with onchocerciasis was analyzed for antibody to O. volvulus antigens using ELISA and Western blot techniques. Significantly higher levels of immunoglobulin against O. volvulus were demonstrated in Chachi Indians compared to native Blacks of African origin: total Ig (p = 0.049), IgG (P = 0.002) IgG4 (p = 0.019) and IgA (p = 0.035). Western blot analysis of sera from 41 persons demonstrated more intense and more frequent recognition of low molecular weight parasite antigens in the Chachi compared to a similar group of male and female Ecuadorian Blacks. These data suggest that the intensity of antibody responses to O. volvulus antigens may reflect the influence of racial factors in the pathogenesis of onchocerciasis in Ecuador.

Author List

Kron MA, Sisley B, Guderian RH, Mackenzie CD, Chico M, Jurado H, Rumbea Guzman J

Author

Michael Kron MD Director, Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
African Continental Ancestry Group
Animals
Antibodies, Helminth
Antigens, Helminth
Blotting, Western
Ecuador
Enzyme-Linked Immunosorbent Assay
Female
Helminthiasis
Humans
Immunoglobulins
Indians, South American
Intestinal Diseases, Parasitic
Male
Molecular Weight
Onchocerca volvulus
Onchocerciasis
jenkins-FCD Prod-410 e9586552fe7f53c71f7923aa6e27aeabbd3c2473