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Neonatal alloimmune thrombocytopenia due to a new platelet-specific alloantibody. Blood 1993 Jun 15;81(12):3318-23

Date

06/15/1993

Pubmed ID

8507868

Scopus ID

2-s2.0-0027319752   24 Citations

Abstract

An infant with severe neonatal alloimmune thrombocytopenia is described in whom an antibody directed at a new platelet-specific alloantigen, Ca (HPA-6b), is implicated. The new alloantigen is of low frequency in the population and was localized to platelet glycoprotein (GP) IIIa. Immunoprecipitation studies using murine monoclonal antibodies specific for the GP complex IIb-IIIa and GPIIIa alone (AP2 and AP3) suggest that the location of the Ca epitope on GPIIIa may be near the binding site for AP3. Neonatal alloimmune thrombocytopenia associated with Ca is likely to be as severe as that seen in cases due to incompatibilities for the HPA-1 (PIA) and HPA-4 (Pen) platelet alloantigen systems, because each is located on GPIIIa, a densely represented molecule on the platelet surface.

Author List

McFarland JG, Blanchette V, Collins J, Newman PJ, Wang R, Aster RH

Author

Richard H. Aster MD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Antigens, Human Platelet
Blood Platelets
Diseases in Twins
Female
Humans
Immunophenotyping
Infant, Newborn
Isoantibodies
Male
Pedigree
Platelet Membrane Glycoproteins
Thrombocytopenia
jenkins-FCD Prod-387 b0ced2662056320369de4e5cd5f21c218c03feb3