Faculty Collaboration Database

Rate of neural recovery in implanted children with auditory neuropathy spectrum disorder. Otolaryngol Head Neck Surg 2011 Feb;144(2):274-9

Date

04/16/2011

Pubmed ID

21493430

DOI

10.1177/0194599810391603

Scopus ID

2-s2.0-79959603771 (requires institutional sign-in at Scopus site)   28 Citations

Abstract

OBJECTIVES: The study objectives were to compare the rate of neural recovery and speech perception performance in children with auditory neuropathy spectrum disorder (ANSD) and children with sensorineural hearing loss (SNHL) from other etiologies.

STUDY DESIGN: Cohort study.

SETTING: Academic hospital and cochlear implant center.

SUBJECTS AND METHODS: Ten children with ANSD were matched based on type of implant and age at implantation with peers diagnosed with SNHL. Electrically evoked compound action potential (ECAP) recovery functions were obtained to measure neural refractory behaviors in response to stimulation from the cochlear implant. Speech perception performance was measured using speech recognition thresholds (SRTs) for monosyllable and spondee word stimuli. These outcome measures were compared between groups.

RESULTS: There was no difference in average recovery function exponent in children with ANSD compared to children with SNHL. Similarly, there were no differences in average SRTs in quiet and in noise in children with ANSD compared to children with SNHL. Relationships between SRT and recovery rate were not present within groups or for all subjects for SRT in quiet, but a significant relationship was found for all subjects for SRT in noise (P = .04).

CONCLUSIONS: Dyssynchronous neural activity in ANSD may affect temporal encoding of electrical stimulation from a cochlear implant. As a group, children with ANSD did not demonstrate slower neural recovery compared to those with SNHL, but there was slower neural recovery observed for some subjects. The utility of ECAP recovery functions on optimizing the stimulation rate for individual patients with ANSD requires further investigation.

Author List

Fulmer SL, Runge CL, Jensen JW, Friedland DR

Authors

David R. Friedland MD Associate Director, Director, Chief, Professor in the Otolaryngology department at Medical College of Wisconsin
Christina Runge PhD Associate Provost, Chief, Professor in the Otolaryngology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adolescent
Auditory Threshold
Child
Child, Preschool
Cochlear Implants
Evoked Potentials, Auditory, Brain Stem
Follow-Up Studies
Hearing
Hearing Loss, Central
Humans
Recovery of Function
Speech Perception
Treatment Outcome