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"Early death" and the contraindication of vaccine during treatment of rabies. Vaccine 2009 Nov 27;27(51):7173-7

Date

11/21/2009

Pubmed ID

19925949

DOI

10.1016/j.vaccine.2009.09.032

Scopus ID

2-s2.0-71549117566   17 Citations

Abstract

Administration of rabies vaccine or rabies immune globulin (RIG) during symptomatic rabies is ineffective, and there are concerns about the phenomenon of "early death" reported in animals that develop rabies after receipt of rabies vaccine or immune globulin. Survival analyses of the original animal data confirm these findings in two species, whereas analyses of human case reports and the Milwaukee Protocol registry suggest lower risk of "early death" in humans. There may be a deleterious interaction of rabies vaccine and RIG with bat rabies in humans. Animal studies of bat rabies virus with bat-origin vaccines and RIG are urgently needed.

Author List

Willoughby RE Jr

Author

Rodney E. Willoughby MD Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Contraindications
Humans
Immunoglobulins
Kaplan-Meier Estimate
Post-Exposure Prophylaxis
Rabies
Rabies Vaccines
jenkins-FCD Prod-398 336d56a365602aa89dcc112f077233607d6a5abc