Risk factors for ischemic ocular motor nerve palsies. Arch Ophthalmol 1994 Jul;112(7):961-6
Date
07/01/1994Pubmed ID
8031277DOI
10.1001/archopht.1994.01090190109029Scopus ID
2-s2.0-0028307408 (requires institutional sign-in at Scopus site) 85 CitationsAbstract
OBJECTIVE: To identify risk factors associated with neurologically isolated ischemic ocular motor nerve palsies.
DESIGN: Case-control study.
SETTING: Multispecialty clinic providing primary, secondary, and tertiary care in central and northern Wisconsin.
STUDY PARTICIPANTS: After applying strict, predetermined, inclusion and exclusion criteria to the medical records of patients with ocular motor nerve palsies, 65 case patients 50 years of age or older were identified with ischemic ophthalmoplegia. A control subject, matched for sex and exact year of age, was randomly selected for each case patient from individuals undergoing a comprehensive medical evaluation.
MAIN OUTCOME MEASURES: Prevalence of potential risk factors in case patients and controls, including diabetes, hypertension, hypercholesterolemia, coronary artery disease, left ventricular hypertrophy, adiposity, tobacco use, prior ocular motor nerve palsy, and hematocrit. Risk factors were assessed using standardized definitions.
RESULTS: After adjustment for potential confounding factors, significant risk factors and their associated odds ratios (ORs) and 95% confidence intervals (CIs) were as follows: previously diagnosed diabetes, OR = 5.75 (CI = 1.68 to 19.7); left ventricular hypertrophy, OR = 5.20 (CI = 1.30 to 20.82); and, hematocrit (per percentage increase), OR = 1.35 (CI = 1.13 to 1.61).
CONCLUSION: In addition to the generally accepted risk factor of diabetes, left ventricular hypertrophy and elevated hematocrit appeared to be important determinants of ischemic ocular motor nerve palsy. Additional studies should be undertaken to confirm these findings.
Author List
Jacobson DM, McCanna TD, Layde PMMESH terms used to index this publication - Major topics in bold
AgedAged, 80 and over
Case-Control Studies
Female
Humans
Ischemia
Male
Middle Aged
Oculomotor Nerve
Oculomotor Nerve Diseases
Odds Ratio
Ophthalmoplegia
Prevalence
Risk Factors