Faculty Collaboration Database

Effect of chronic renal medullary nitric oxide inhibition on blood pressure. Am J Physiol 1994 May;266(5 Pt 2):H1918-26

Date

05/11/1994

Pubmed ID

8203591

DOI

10.1152/ajpheart.1994.266.5.H1918

Scopus ID

2-s2.0-0028121625 (requires institutional sign-in at Scopus site)   194 Citations

Abstract

The effects of chronic nitric oxide inhibition in the renal medulla on renal cortical and medullary blood flow, sodium balance, and blood pressure were evaluated in conscious uninephrectomized Sprague-Dawley rats. During a 5-day renal medullary interstitial infusion of the nitric oxide inhibitor NG-nitro-L-arginine methyl ester (L-NAME, 120 micrograms/h) in saline (0.5 ml/min), renal medullary blood flow was selectively decreased by 30% after 2 h and was maintained at that level for the entire infusion. The decrease in medullary blood flow was associated with sodium retention and increased blood pressure. After the cessation of L-NAME infusion, medullary blood flow returned to control, and the sodium balance became negative as blood pressure returned to baseline. These data indicate that renal medullary nitric oxide plays an important role in the regulation of renal blood flow, sodium excretion, and blood pressure.

Author List

Mattson DL, Lu S, Nakanishi K, Papanek PE, Cowley AW Jr

Authors

Allen W. Cowley Jr PhD Professor in the Physiology department at Medical College of Wisconsin
Paula Papanek PhD, MPT, LAT, FACSM Associate Professor & Director of Exercise Science in the Exercise Science & Physical Therapy department at Marquette University

MESH terms used to index this publication - Major topics in bold

Animals
Arginine
Blood Pressure
Infusions, Parenteral
Injections, Intravenous
Kidney Cortex
Kidney Medulla
NG-Nitroarginine Methyl Ester
Nephrectomy
Nitric Oxide
Rats
Rats, Sprague-Dawley
Reference Values
Regional Blood Flow
Renal Circulation
Time Factors