[The ligand-dependent phosphorylation of epidermal growth factor receptors and the production of a secreted form of the receptor by cell strains of A-431 epidermoid carcinoma]. Tsitologiia 1990;32(10):1026-30
Date
01/01/1990Pubmed ID
2082511Scopus ID
2-s2.0-0025674721 (requires institutional sign-in at Scopus site)Abstract
Primary reactions on the addition of the epidermal growth factor (EGF) were investigated for the strains of A-431 cells, resistant to the antiproliferative effect of EGF. In spite of differences of EGF reception in the obtained strains, the EGF receptors in membrane preparations of these strains maintain the phosphorylating ability after addition of EGF. The rate of internalization of 125I-EGF in normal and resistant cells is the same. The production of a secreted fragment of the EGF receptor in resistant cells is lower than in normal ones. Questions of regulation of production of the normal receptor and of its shortened secreted fragment are discussed.
Author List
Sorokin AB, Gudkova DA, Kudriavtseva NV, Nikol'skiĭ NNAuthor
Andrey Sorokin PhD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Carcinoma, Squamous CellCell Division
Cell Line
Drug Resistance
Epidermal Growth Factor
ErbB Receptors
Humans
Iodine Radioisotopes
Ligands
Phosphorylation
Tumor Cells, Cultured