Faculty Collaboration Database

[The ligand-dependent phosphorylation of epidermal growth factor receptors and the production of a secreted form of the receptor by cell strains of A-431 epidermoid carcinoma]. Tsitologiia 1990;32(10):1026-30

Date

01/01/1990

Pubmed ID

2082511

Scopus ID

2-s2.0-0025674721 (requires institutional sign-in at Scopus site)

Abstract

Primary reactions on the addition of the epidermal growth factor (EGF) were investigated for the strains of A-431 cells, resistant to the antiproliferative effect of EGF. In spite of differences of EGF reception in the obtained strains, the EGF receptors in membrane preparations of these strains maintain the phosphorylating ability after addition of EGF. The rate of internalization of 125I-EGF in normal and resistant cells is the same. The production of a secreted fragment of the EGF receptor in resistant cells is lower than in normal ones. Questions of regulation of production of the normal receptor and of its shortened secreted fragment are discussed.

Author List

Sorokin AB, Gudkova DA, Kudriavtseva NV, Nikol'skiĭ NN

Author

Andrey Sorokin PhD Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Carcinoma, Squamous Cell
Cell Division
Cell Line
Drug Resistance
Epidermal Growth Factor
ErbB Receptors
Humans
Iodine Radioisotopes
Ligands
Phosphorylation
Tumor Cells, Cultured