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High-resolution typing for unrelated donor transplantation: how far do we go? Best Pract Res Clin Haematol 2009 Dec;22(4):537-41 PMID: 19959105 PMCID: PMC2904986

Pubmed ID

19959105

Abstract

For best results with unrelated donor transplantation of acute myeloid leukaemia (AML) patients, high-resolution typing should be completed for human leucocyte antigens (HLAs) A, B, C and DR. In the absence of an HLA-identical sibling, an unrelated adult donor, fully matched or with a single mismatch at these loci, should be used. If such a donor is not available in a timely manner, cord blood mismatched at one or two loci may be used. Data also suggest that peripheral blood transplantation may be more permissive of HLA mismatching than bone marrow transplants. Transplant decisions should be based on several factors, including availability of matched donors, as well as patient age, performance status and disease stage.

Author List

Horowitz MM

Author

Mary M. Horowitz MD, MS Center Director, Professor in the Medicine department at Medical College of Wisconsin




Scopus

2-s2.0-71749109588   13 Citations

MESH terms used to index this publication - Major topics in bold

Histocompatibility Testing
Humans
Leukemia, Myeloid, Acute
Stem Cell Transplantation
Tissue Donors
jenkins-FCD Prod-300 626508253d14e4184314fb9f66322a03a5906796