Faculty Collaboration Database

Control of ACTH and vasopressin in neurohypophysectomized conscious dogs. Am J Physiol 1985 Aug;249(2 Pt 2):R281-4

Date

08/11/1985

Pubmed ID

2992297

DOI

10.1152/ajpregu.1985.249.2.R281

Scopus ID

2-s2.0-0022103073 (requires institutional sign-in at Scopus site)   13 Citations

Abstract

Adrenocorticotropin (ACTH), cortisol, and vasopressin responses to clamped decreases in blood pressure (MAP) and to ovine corticotropin-releasing factor (CRF) infusion (20 ng X kg-1 X min-1) in intact and neurohypophysectomized (NHX) conscious dogs were examined. Mean arterial blood pressure was decreased 28 mmHg by a controlled infusion of sodium nitroprusside. Hypotension induced large increases in ACTH (peak 164 +/- 25 pg/ml), cortisol (peak 12.5 +/- 2.5 micrograms/dl), and vasopressin (peak 221 +/- 64 pg/ml) in intact (n = 7) dogs. NHX (n = 7) significantly attenuated these responses to hypotension. CRF infusion induced increases in ACTH similar in intact (n = 4) and NHX (n = 4) dogs. However, cortisol responses were significantly attenuated by NHX. Interestingly, CRF infusion induced small but significant increases in vasopressin from 3.0 +/- 1.1 to 8.1 +/- 2.0 pg/ml. We conclude that NHX attenuates ACTH and vasopressin responses to hypotension and cortisol responses to CRF-induced increases in ACTH. CRF seems to stimulate vasopressin release.

Author List

Raff H, Merrill D, Skelton M, Cowley AW Jr

Authors

Allen W. Cowley Jr PhD Professor in the Physiology department at Medical College of Wisconsin
Hershel Raff PhD Professor in the Academic Affairs department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adrenocorticotropic Hormone
Animals
Blood Pressure
Corticotropin-Releasing Hormone
Dogs
Heart Rate
Hydrocortisone
Hypophysectomy
Hypotension
Male
Nitroprusside
Pituitary Gland, Posterior
Vasopressins