Plasma substance P levels in normotensive and hypertensive subjects. Clin Exp Hypertens (1978) 1981;3(2):183-93
Date
01/01/1981Pubmed ID
6163596DOI
10.3109/10641968109033659Scopus ID
2-s2.0-0019831528 (requires institutional sign-in at Scopus site) 5 CitationsAbstract
Since substance P is a potent natriuretic, diuretic, and vasodilatory peptide, a radioimmunoassay for substance P was developed, and its levels measured in the plasma of normal subjects and patients with essential hypertension. The plasma substance P levels were 186+/-14 pg/ml in normal subjects and 164+/-3 pg/ml in hypertensive patients. When the sodium content of their diet was reduced to 10 mEq/day, substance P levels failed to change, but plasma renin activity and urinary kallikrein increased. An acute saline infusion also failed to alter plasma substance P levels. Assuming an upright posture increased plasma renin activity, but not substance P, in both groups of subjects. Thus, it appears that substance P is not involved in the control of blood pressure, kallikrein excretion or renin release in man.
Author List
Campbell WB, Holland OB, Gomez-Sanchez CE, Graham RM, Pettinger WA, White ACAuthor
William B. Campbell PhD Professor in the Pharmacology and Toxicology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
DietHumans
Hypertension
Posture
Radioimmunoassay
Sodium
Substance P