Medical College of Wisconsin
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Effect of indomethacin on hydralazine-induced renin and catecholamine release in the conscious rabbit. Br J Pharmacol 1980;71(2):529-31 PMID: 7008885 PMCID: PMC2044447

Pubmed ID

7008885

Abstract

1. The effects of hydralazine on mean arterial pressure (MAP) heart rate (HR), plasma renin activity (PRA) and plasma catecholamines were examined in conscious rabbits before and after prostaglandin synthesis inhibition with indomethacin. 2. Hydralazine (3 mg/kg. i.v.) produced a 12% decrease in MAP and significant increases in HR, PRA and plasma noradrenaline and adrenaline. 3. Indomethacin (5 mg/kg, s.c.) failed to alter significantly the control MAP, HR, PRA or plasma catecholamines but inhibited renal venous prostaglandin E2 by 56% (P less than 0.02). 4. Indomethacin inhibited the hydralazine-induced tachycardia by 24% and augmented its hypotensive effects by 6%. 5. The hydralazine-stimulated increase in PRA was also inhibited 75% (P less than 0.001) by indomethacin whereas noradrenaline and adrenaline concentrations were not significantly reduced. 6. Indomethacin inhibits hydralazine-induced renin release in the presence of elevated concentrations of plasma catecholamines; these findings suggest that renal prostaglandins function as important mediators of sympathetically-induced renin release.

Author List

Campbell WB, Graham RM, Jackson EK, Loisel DP, Pettinger WA

Author

William B. Campbell PhD Chair, Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin




Scopus

2-s2.0-0019212185   10 Citations

MESH terms used to index this publication - Major topics in bold

Animals
Catecholamines
Drug Interactions
Female
Heart Rate
Hydralazine
Indomethacin
Male
Rabbits
Renin
jenkins-FCD Prod-353 9ccd8489072cb19f5b9f808bb23ed672c582f41e