Peripheral beta-receptor responsiveness in patients with essential hypertension. Arch Intern Med 1979 Aug;139(8):879-81
Date
08/01/1979Pubmed ID
223509Scopus ID
2-s2.0-84942560284 (requires institutional sign-in at Scopus site) 26 CitationsAbstract
Peripheral beta-adrenergic receptor sensitivity was characterized in 24 patients with essential hypertension and in 13 age-matched normotensive subjects using an isoproterenol hydrochloride bolus dose-response technique. Decreased beta-receptor responsiveness to this exogenously administered beta-agonist was observed in hypertensive patients; for an equivalent chronotropic effect, higher doses of isoproterenol were required in hypertensive subjects than in normal subjects. Among "normal-renin" hypertensive patients, beta-receptor responsiveness was directly related to furosemide-stimulated plasma renin activity (PRA), suggesting that independently stimulated PRA may provide an indirect estimate of endogenous beta-receptor sensitivity. Hypertensive patients whose mean arterial pressure fell at least 10 mm Hg after four weeks of treatment with hydrochlorothiazide had even further depression in beta-receptor responsiveness, whereas receptor sensitivity was unchanged in patients whose blood pressure was unaffected. Thus, it is unlikely that this decreased receptor responsiveness in patients with untreated essential hypertension is a direct consequence of elevated arterial pressure.
Author List
McAllister RG Jr, Love DW, Guthrie GP Jr, Dominic JA, Kotchen TAMESH terms used to index this publication - Major topics in bold
AdultBlood Pressure
Dose-Response Relationship, Drug
Female
Furosemide
Humans
Hydrochlorothiazide
Hypertension
Isoproterenol
Male
Middle Aged
Receptors, Adrenergic
Receptors, Adrenergic, beta
Renin