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Effect of right atrial pacing and nitroglycerin on myocardial oxygen balance. Eur J Pharmacol 1975 Nov;34(1):229-32

Date

11/01/1975

Pubmed ID

826400

DOI

10.1016/0014-2999(75)90244-7

Scopus ID

2-s2.0-0016837321 (requires institutional sign-in at Scopus site)   3 Citations

Abstract

The direct effects or right atrial pacing and nitroglycerin on myocardial oxygen balance were studied in isolated canine hearts. Whereas atrial pacing produced an increase in myocardial oxygen consumption (MVO2) and no change in the affinity of hemoglobin for oxygen (P-50), an intracoronary infusion of nitroglycerin decreased both MVO2 and the affinity of hemoglobin for oxygen (increased P-50) in coronary venous blood. Under conditions of a constant coronary blood flow, nitroglycerin may benefit a hypoxic myocardium by reducing oxygen demand and by increasing availability of oxygen for rapid diffusion to tissue by increasing P-50.

Author List

Warltier DC, Gross GJ, Hardman HF

MESH terms used to index this publication - Major topics in bold

Animals
Atrial Function
Coronary Circulation
Dogs
Electric Stimulation
Hemoglobins
Myocardium
Nitroglycerin
Oxygen Consumption