Faculty Collaboration Database

Intensive alternating drug pairs after remission induction for treatment of infants with acute lymphoblastic leukemia: A Pediatric Oncology Group Pilot Study. J Pediatr Hematol Oncol 1998;20(3):229-33

Date

06/17/1998

Pubmed ID

9628434

DOI

10.1097/00043426-199805000-00008

Scopus ID

2-s2.0-0031813927 (requires institutional sign-in at Scopus site)   24 Citations

Abstract

PURPOSE: Infants with acute lymphoblastic leukemia (ALL) often enter remission; however, they have a high rate of relapse. To prevent relapse, infants' tolerance of and benefits from early intensive rotating drug pairs as part of therapy were studied.

METHODS: After prednisone, vincristine, asparaginase, and daunorubicin induction, 12 intensive treatments (ABACABACABAC) were administered in 30 weeks: A, intermediate dose methotrexate (MTX) and intermediate dose mercaptopurine (MP); B, cytosine arabinoside (Ara-C) and daunorubicin (DNR); C, Ara-C and teniposide (VM-26). Triple intrathecal chemotherapy (Ara-C, MTX, and hydrocortisone) was administered for central nervous system prophylaxis. Continuation therapy consisted of weekly MTX and daily MP for a total of 130 weeks of continuous complete remission.

RESULTS: Thirty-three infants (1 year old or younger) with newly diagnosed ALL were treated. Two infants did not respond to induction, 1 died from sepsis during continuation, 1 received a bone marrow transplant, and 24 relapsed. Median time to relapse was 39 weeks. The event-free survival rate at 5 years was 17% (standard error +/- 7.7%). The most significant toxicities occurred during intensification and included fever-neutropenia and bacterial sepsis.

CONCLUSION: Although early intensive rotating therapy is tolerable, the relapse-free survival rate remains poor for infants treated with the schedule on this protocol.

Author List

Lauer SJ, Camitta BM, Leventhal BG, Mahoney D Jr, Shuster JJ, Kiefer G, Pullen J, Steuber CP, Carroll AJ, Kamen B

MESH terms used to index this publication - Major topics in bold

Antineoplastic Combined Chemotherapy Protocols
Cytarabine
Daunorubicin
Disease-Free Survival
Drug Therapy, Combination
Female
Humans
Hydrocortisone
Infant
Injections, Spinal
Male
Mercaptopurine
Methotrexate
Pilot Projects
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Remission Induction
Teniposide