The effect of intestinal permeability on pancreatic enzyme-induced enteropathy in the rat. J Pediatr Gastroenterol Nutr 1998 May;26(5):489-95
Date
05/20/1998Pubmed ID
9586757DOI
10.1097/00005176-199805000-00001Scopus ID
2-s2.0-0031921582 (requires institutional sign-in at Scopus site) 14 CitationsAbstract
BACKGROUND: Fibrosing colonopathy in cystic fibrosis occurs in children 2 to 7 years old and is associated with excess doses of high and regular strength lipase pancreatic enzymes, given for more than 6 months. A rat model was developed to study the effects of excessive doses of pancreatic enzymes equivalent to those producing fibrosing colonopathy in cystic fibrosis patients.
METHODS: Five groups of animals were studied after administration of different combinations of pancreatic enzymes, oleic acid, and reserpine.
RESULTS: Pancreatic enzymes alone produced minimal damage to the intestine and none to the liver. Excessive doses of pancreatic enzymes in combination with agents that increased intestinal permeability (oleic acid, reserpine) were associated with intestinal eosinophilia and necrosis of the jejunoileal muscle layer and inflammatory nodules in the liver, which increased with duration of insult.
CONCLUSIONS: Increased intestinal permeability potentiates damage to the intestine caused by excessive pancreatic enzyme dosage. It is a characteristic of cystic fibrosis that may increase vulnerability to fibrosing colonopathy.
Author List
Lloyd-Still JD, Uhing MR, Arango V, Fusaro A, Kimura REAuthor
Michael R. Uhing MD Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsCell Membrane Permeability
Eosinophilia
Intestinal Diseases
Intestines
Lipase
Liver
Necrosis
Oleic Acid
Rats
Rats, Sprague-Dawley
Reserpine
