Radiation dose-volume effects in the stomach and small bowel. Int J Radiat Oncol Biol Phys 2010 Mar 01;76(3 Suppl):S101-7
Date
03/05/2010Pubmed ID
20171503DOI
10.1016/j.ijrobp.2009.05.071Scopus ID
2-s2.0-76449104629 (requires institutional sign-in at Scopus site) 409 CitationsAbstract
Published data suggest that the risk of moderately severe (>or=Grade 3) radiation-induced acute small-bowel toxicity can be predicted with a threshold model whereby for a given dose level, D, if the volume receiving that dose or greater (VD) exceeds a threshold quantity, the risk of toxicity escalates. Estimates of VD depend on the means of structure segmenting (e.g., V15 = 120 cc if individual bowel loops are outlined or V45 = 195 cc if entire peritoneal potential space of bowel is outlined). A similar predictive model of acute toxicity is not available for stomach. Late small-bowel/stomach toxicity is likely related to maximum dose and/or volume threshold parameters qualitatively similar to those related to acute toxicity risk. Concurrent chemotherapy has been associated with a higher risk of acute toxicity, and a history of abdominal surgery has been associated with a higher risk of late toxicity.
Author List
Kavanagh BD, Pan CC, Dawson LA, Das SK, Li XA, Ten Haken RK, Miften MMESH terms used to index this publication - Major topics in bold
Antineoplastic Combined Chemotherapy ProtocolsHumans
Intestine, Small
Models, Biological
Radiation Injuries
Radiation Tolerance
Radiography
Radiotherapy Dosage
Risk
Stomach