Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Spectral domain optical coherence tomography and adaptive optics: imaging photoreceptor layer morphology to interpret preclinical phenotypes. Adv Exp Med Biol 2010;664:309-16 PMID: 20238030 PMCID: PMC3444150

Pubmed ID

20238030

DOI

10.1007/978-1-4419-1399-9_35

Abstract

Recent years have seen the emergence of advances in imaging technology that enable in vivo evaluation of the living retina. Two of the more promising techniques, spectral domain optical coherence tomography (SD-OCT) and adaptive optics (AO) fundus imaging provide complementary views of the retinal tissue. SD-OCT devices have high axial resolution, allowing assessment of retinal lamination, while the high lateral resolution of AO allows visualization of individual cells. The potential exists to use one modality to interpret results from the other. As a proof of concept, we examined the retina of a 32 year-old male, previously diagnosed with a red-green color vision defect. Previous AO imaging revealed numerous gaps throughout his cone mosaic, indicating that the structure of a subset of cones had been compromised. Whether the affected cells had completely degenerated or were simply morphologically deviant was not clear. Here an AO fundus camera was used to re-examine the retina (~6 years after initial exam) and SD-OCT to examine retinal lamination. The static nature of the cone mosaic disruption combined with the normal lamination on SD-OCT suggests that the affected cones are likely still present.

Author List

Rha J, Dubis AM, Wagner-Schuman M, Tait DM, Godara P, Schroeder B, Stepien K, Carroll J

Author

Joseph J. Carroll PhD Director, Professor in the Ophthalmology and Visual Sciences department at Medical College of Wisconsin




Scopus

2-s2.0-78650616128   22 Citations

MESH terms used to index this publication - Major topics in bold

Adult
Amino Acid Sequence
Humans
Image Processing, Computer-Assisted
Male
Middle Aged
Molecular Sequence Data
Opsins
Optics and Photonics
Phenotype
Photoreceptor Cells, Vertebrate
Retinal Cone Photoreceptor Cells
Tomography, Optical Coherence
Young Adult
jenkins-FCD Prod-353 9ccd8489072cb19f5b9f808bb23ed672c582f41e