In-111 WBC imaging of osteomyelitis in patients with underlying bone scan abnormalities. Clin Nucl Med 1996 Mar;21(3):183-91
Date
03/01/1996Pubmed ID
8846561DOI
10.1097/00003072-199603000-00001Scopus ID
2-s2.0-0029991259 (requires institutional sign-in at Scopus site) 39 CitationsAbstract
One hundred seven combined In-111 WBC/Tc-99m MDP scans performed on 87 patients with a high clinical suspicion of osteomyelitis were retrospectively reviewed. An 86% sensitivity and a 94% specificity for detecting osteomyelitis were found. In addition, patients were grouped into one of five clinical settings for more detailed analysis: diabetic osteoarthropathy, previous arthroplasty, fracture, overlying skin ulcer, and other etiology. Forty-seven studies were performed while patients received antibiotic therapy without loss of sensitivity for detecting osteomyelitis. Results obtained with scintigraphy compared favorably to other imaging and laboratory studies used to detect osteomyelitis. In conclusion, the combined In-111 WBC/Tc-99m MDP scan is a very sensitive and specific method to detect osteomyelitis in patients with concurrent diabetic osteoarthropathy, fracture, postoperative healing, and overlying skin ulcer. Antibiotic treatment does not appear to adversely affect the sensitivity of these scans.
Author List
Kolindou A, Liu Y, Ozker K, Krasnow AZ, Isitman AT, Hellman RS, Collier BDMESH terms used to index this publication - Major topics in bold
Anti-Bacterial AgentsArthroplasty
Bone and Bones
Diabetes Complications
Diagnostic Imaging
Female
Fractures, Bone
Humans
Indium Radioisotopes
Leukocytes
Male
Middle Aged
Osteomyelitis
Radionuclide Imaging
Retrospective Studies
Sensitivity and Specificity
Skin Ulcer
Technetium Tc 99m Medronate