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Risk factors of cholestasis in very low-birth-weight infants. Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi 1996 Jul-Aug;37(4):278-82

Date

07/01/1996

Pubmed ID

8854350

Scopus ID

2-s2.0-0030185045   5 Citations

Abstract

To evaluate the incidence, clinical course, and possible risk factors of cholestasis in very low-birth-weight infants. A retrospective study of 143 very low-birth-weight infants was performed. Cholestasis was defined as direct-reacting bilirubin > 2 mg/dL for more than 14 days. The clinical course of cholestasis was described, and perinatal risk factors were evaluated for associations with the development and severity of cholestasis. Cholestasis was present in 31 infants (21.7%). The mean (SD) age of onset was 30.3(15.3) days after birth or 26.0 (15.6) days after receiving parenteral nutrition, and the mean (SD) duration was 77.1 (33.8) days. In half of the cholestatic infants, bilirubin continued to rise after discontinuing parenteral nutrition. One infant developed signs of liver cirrhosis and died, two infants died with progressive cholestasis, while the other 28 patients recovered. Analysis of risk factors revealed that birthweight and duration of fasting significantly correlated with the development of cholestasis, and that sepsis significantly influenced the severity of cholestasis. Cholestasis is a common complication of extreme prematurity. The clinical course seems benign but long-term sequelae are unknown. Immature liver function and absence of stimuli for intestinal motility and hormonal secretion predispose to decreased bile flow, while sepsis further impairs hepatic ductular secretion and aggravates cholestasis.

Author List

Wu TJ, Teng RJ, Yau KI

Authors

Ru-Jeng Teng MD Associate Professor in the Pediatrics department at Medical College of Wisconsin
Tzong-Jin Wu MD Associate Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Bile
Bilirubin
Female
Humans
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature
Jaundice, Neonatal
Liver
Male
Retrospective Studies
Risk Factors
jenkins-FCD Prod-411 e00897e83867fcfa48419861683711f8d99adb75