Newer diagnostic techniques and problems in Cushing's disease. Endocrinol Metab Clin North Am 1999 Mar;28(1):191-210
Date
04/20/1999Pubmed ID
10207691DOI
10.1016/s0889-8529(05)70063-3Scopus ID
2-s2.0-0032912144 (requires institutional sign-in at Scopus site) 67 CitationsAbstract
The best diagnostic approach to patients with suspected Cushing's disease continues to evolve. The introduction of transsphenoidal pituitary surgery as the treatment of choice for Cushing's disease as well as the absence of any pituitary imaging abnormalities in many patients with Cushing's disease has made accurate diagnosis and differential diagnosis essential. In the authors' opinion, two or three late night (11 PM) salivary cortisol determinations and the measurement of 24-hour UFC are the best and simplest means to evaluate patients with suspected hypercortisolism. L-DST can no longer be recommended to exclude the diagnosis of Cushing's disease, particularly if the hypercortisolism is mild. The combination of L-DST and CRH stimulation is a new and apparently sensitive means to establish the presence or absence of pathologic hypercortisolism in equivocal cases. In the absence of an overt pituitary tumor on MR imaging, inferior petrosal sinus sampling with CRH stimulation should be performed to secure the diagnosis of Cushing's disease as well as identify the probable location of the corticotroph adenoma.
Author List
Findling JW, Raff HAuthors
James W. Findling MD Professor in the Medicine department at Medical College of WisconsinHershel Raff PhD Professor in the Academic Affairs department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
Adrenocorticotropic HormoneCircadian Rhythm
Corticotropin-Releasing Hormone
Cushing Syndrome
Deamino Arginine Vasopressin
Dexamethasone
Diagnosis, Differential
Glucocorticoids
Humans
Hydrocortisone
Saliva