Faculty Collaboration Database

Penetration of meropenem in plasma and abdominal tissues from patients undergoing intraabdominal surgery. Clin Infect Dis 1997 Feb;24 Suppl 2:S181-3

Date

02/01/1997

Pubmed ID

9126691

DOI

10.1093/clinids/24.supplement_2.s181

Scopus ID

2-s2.0-0030892140 (requires institutional sign-in at Scopus site)   29 Citations

Abstract

We assessed the penetration of a new carbapenem antibiotic, meropenem, into abdominal tissues. A single 1,000-mg intravenous dose was administered to 66 patients undergoing elective intraabdominal surgery. Plasma, body fluid (peritoneal fluid and bile), and tissue samples (colon, gallbladder, omentum, stomach, fascia, muscle, and skin) were taken at various times up to 8 hours after administration of the dose. Meropenem concentrations were determined by means of validated bioassay techniques. Peak meropenem concentrations in most tissue specimens and one body fluid occurred within approximately 1 hour; the exceptions were bile and muscle specimens, in which peak concentrations were present in approximately 2 to approximately 4 hours. The bile concentration increased with time, thus indicating active excretion of drug into bile. Only one adverse event (mild nausea) was attributable to meropenem. Our results show that meropenem achieves adequate tissue concentrations for the treatment of intraabdominal infections due to susceptible bacteria.

Author List

Condon RE, Walker AP, Hanna CB, Greenberg RN, Broom A, Pitkin D

MESH terms used to index this publication - Major topics in bold

Anti-Bacterial Agents
Ascitic Fluid
Bile
Colon
Elective Surgical Procedures
Fascia
Female
Gallbladder
Gastric Mucosa
Gram-Negative Bacteria
Gram-Positive Bacteria
Hospitalization
Humans
Male
Microbial Sensitivity Tests
Middle Aged
Muscles
Omentum
Plasma
Skin
Thienamycins