ROS-induced ROS release in vascular biology: redox-redox signaling. Am J Physiol Heart Circ Physiol 2011 Sep;301(3):H647-53
Date
06/21/2011Pubmed ID
21685266Pubmed Central ID
PMC3191081DOI
10.1152/ajpheart.01271.2010Scopus ID
2-s2.0-80052305695 (requires institutional sign-in at Scopus site) 133 CitationsAbstract
The involvement of reactive oxygen species (ROS) in regulating vascular function both in normal vessels and as part of an adaptive response during disease has been intensively studied. From the recognition that ROS serve as important signaling molecules has emerged multiple lines of evidence that there is a functional connectivity between intracellular sites of ROS production. This cross talk has been termed ROS-induced ROS release (RIRR) and is supported by a variety of observations showing that RIRR is a common mechanism for ROS amplification and regional ROS generation. The compartmentalization of ROS production within a cell is critical to its signaling function and is facilitated by microlocalization of specific scavengers. This review will provide descriptions and examples of important mechanisms of RIRR.
Author List
Zinkevich NS, Gutterman DDAuthor
Natalya S. Zinkevich PhD Research Scientist I in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAntioxidants
Blood Vessels
Humans
Mitochondria
NADPH Oxidases
Oxidation-Reduction
Oxidative Stress
Reactive Oxygen Species
Signal Transduction
