Effect on breathing of surface ventrolateral medullary cooling in awake, anesthetized and asleep goats. Respir Physiol 1997 Nov;110(2-3):187-97
Date
01/04/1998Pubmed ID
9407611DOI
10.1016/s0034-5687(97)00083-2Scopus ID
2-s2.0-0030712031 (requires institutional sign-in at Scopus site) 38 CitationsAbstract
In adult and neonatal goats, we chronically implanted thermodes on the ventrolateral (VLM) medullary surface to create reversible neuronal dysfunction and thereby gain insight into the role of superficial VLM neurons in control of breathing in anesthetized, awake and asleep states. Consistent with data of others, cooling caudal area M and rostral area S caused sustained apnea under anesthesia. However, in the awake and NREM sleep states, cooling at this site caused only a modest reduction in breathing, indicating that neurons at this site are not critical for respiratory rhythm in these states. Moreover, data in the awake state over multiple conditions suggest neurons at this site do not integrate all intracranial and carotid chemoreception. The data suggest though that neurons at this site have a facilitatory-like effect on breathing both unrelated and related to intracranial chemoreception. We believe that this facilitation serves a function similar to the facilitation provided by the carotid chemoreceptors and by sources associated with wakefulness. Accordingly, elimination/attenuation of any one of these three influences (caudal M rostral S VLM, wakefulness, carotid chemoreception) results in a slight decrease in breathing, removal of two of the three results in a greater decrease in breathing, and removal of all three results in sustained apnea.
Author List
Forster HV, Ohtake PJ, Pan LG, Lowry TFAuthor
Hubert V. Forster PhD Professor in the Physiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnesthesiaAnimals
Animals, Newborn
Blood Pressure
Cold Temperature
Goats
Heart Rate
Medulla Oblongata
Neurons
Respiratory Mechanics
Sleep
Wakefulness