Medical College of Wisconsin
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Preauricular skin defects. A consequence of a persistent ectodermal groove. Arch Dermatol 1997 Dec;133(12):1551-4 PMID: 9420540

Pubmed ID

9420540

Abstract

BACKGROUND: The term aplasia cutis is used to describe congenital localized defects of the skin. This affliction is the end result of various in utero events. Aplasia cutis of the face, although rare, has been associated with numerous dysmorphic features and described under many clinical terms.

OBSERVATIONS: We studied 10 patients with oval, atrophic patches distributed in a linear pattern on the preauricular region of the face. Most of the defects were bilateral, and all consistently fell in an oblique line extending from the preauricular region to the angle of the mouth. This line corresponds to the region of fusion between the maxillary and mandibular facial prominences during embryonic development.

CONCLUSIONS: This type of facial aplasia cutis may be the result of incomplete fusion of the ectodermal groove between the maxillary and mandibular facial prominences. Although other types of facial skin defects may share a similar pathogenic mechanism, they are distinct in that they occur in different regions and may have other abnormal facial features.

Author List

Drolet BA, Baselga E, Gosain AK, Levy ML, Esterly NB



Scopus

2-s2.0-0030733339   29 Citations

MESH terms used to index this publication - Major topics in bold

Biopsy
Ear
Ectodermal Dysplasia
Face
Female
Humans
Infant, Newborn
Male
Skin
Terminology as Topic
jenkins-FCD Prod-332 f92a19b0ec5e8e1eff783fac390ec127e367c2b5