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Signal transducer and activator of transcription 5a/b: biomarker and therapeutic target in prostate and breast cancer. Int J Biochem Cell Biol 2011 Oct;43(10):1417-21

Date

06/28/2011

Pubmed ID

21704724

Pubmed Central ID

PMC3163765

DOI

10.1016/j.biocel.2011.06.007

Abstract

The search for new therapeutic strategies for prostate and breast cancer is of significant interest. Signal transducer and activator of transcription 5a/b (Stat5a/b) controls viability and growth of prostate cancer. Nuclear active Stat5a/b expression is clustered to high grade prostate cancers, predicts early disease recurrence and promotes metastatic dissemination of prostate cancer. In breast cancer, the role of Stat5a/b is more complex. In rodent model systems, Stat5a/b may promote malignant transformation and enhance growth of the breast tumors. In contrast, Stat5a/b activation in established human breast cancer positively correlates with tumor differentiation, prevents metastatic dissemination, and predicts favorable clinical outcome of node-negative breast cancer. Here we review the molecular structure and biological functions of Stat5a/b and discuss the potential applications of Stat5a/b for therapy development and as a prognostic marker for prostate and breast cancer.

Author List

Koptyra M, Gupta S, Talati P, Nevalainen MT

Author

Marja T. Nevalainen MD, PhD Assistant Dean, Professor in the Pathology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Biomarkers, Tumor
Breast Neoplasms
Cell Transformation, Neoplastic
Female
Humans
Male
Molecular Targeted Therapy
Phosphorylation
Prostatic Neoplasms
STAT5 Transcription Factor
Transcriptional Activation
Tumor Suppressor Proteins
jenkins-FCD Prod-403 0f9a74600e4e79798f8fa6f545ea115f3dd948b2