Severe neonatal protein C deficiency: prevalence and thrombotic risk. J Pediatr 1991 Nov;119(5):793-8
Date
11/01/1991Pubmed ID
1834822DOI
10.1016/s0022-3476(05)80305-1Scopus ID
2-s2.0-0025954703 (requires institutional sign-in at Scopus site) 89 CitationsAbstract
Severe deficiencies of protein C, a pivotal coagulation-regulatory protein, have been reported in neonates as an apparently transient condition. In this prospective study, cord blood was collected at 193 deliveries and assays of protein C were correlated with clinical status, other coagulation results, and outcome. Protein C levels of less than 0.1 unit/ml were found most frequently in preterm infants with respiratory distress, infants of diabetic mothers, and infants of twin gestations. Levels of protein C correlated with levels of factor VIII activity but did not correlate with markers of consumptive coagulopathy. A protein C level less than 0.1 unit/ml was significantly correlated with the subsequent onset of thrombosis, even when the effects of gestational age and birth weight were excluded. Low cord blood levels of protein C may reflect delayed maturation or increased turnover in certain infants and appear to convey an independent risk of thrombosis, but the critical concentration of protein C necessary to maintain neonatal hemostasis is not known.
Author List
Manco-Johnson MJ, Abshire TC, Jacobson LJ, Marlar RAMESH terms used to index this publication - Major topics in bold
Antithrombin IIIBlood Proteins
Carrier Proteins
Colorado
Disseminated Intravascular Coagulation
Fetal Blood
Glycoproteins
Heparin Cofactor II
Humans
Infant, Newborn
Prevalence
Protein C
Protein C Deficiency
Protein S
Risk Factors
Thrombosis
