Tn5: A molecular window on transposition. Biochem Biophys Res Commun 1999 Dec 29;266(3):729-34
Date
12/22/1999Pubmed ID
10603311DOI
10.1006/bbrc.1999.1891Scopus ID
2-s2.0-0033616146 (requires institutional sign-in at Scopus site) 42 CitationsAbstract
DNA transposition is an underlying process involved in the remodeling of genomes in all types of organisms. We analyze the multiple steps in cut-and-paste transposition using the bacterial transposon Tn5 as a model. This system is particularly illuminating because of the existence of structural, genetic, and biochemical information regarding the two participating specific macromolecules: the transposase and the 19-bp sequences that define the ends of the transposon. However, most of the insights should be of general interest because of similarities to other transposition-like systems such as HIV-1 DNA integration into the host genome.
Author List
Reznikoff WS, Bhasin A, Davies DR, Goryshin IY, Mahnke LA, Naumann T, Rayment I, Steiniger-White M, Twining SSAuthor
Sally S. Twining PhD Assistant Dean, Professor in the Biochemistry department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Base SequenceDNA
DNA Transposable Elements
Protein Binding
Transposases