Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Leptospira as an emerging pathogen: a review of its biology, pathogenesis and host immune responses. Future Microbiol 2010 Sep;5(9):1413-25 PMID: 20860485 PMCID: PMC3037011

Pubmed ID

20860485

DOI

10.2217/fmb.10.102

Abstract

Leptospirosis, the most widespread zoonosis in the world, is an emerging public health problem, particularly in large urban centers of developing countries. Several pathogenic species of the genus Leptospira can cause a wide range of clinical manifestations, from a mild, flu-like illness to a severe disease form characterized by multiorgan system complications leading to death. However, the mechanisms of pathogenesis of Leptospira are largely unknown. This article will address the animal models of acute and chronic leptospire infections, and the recent developments in the genetic manipulation of the bacteria, which facilitate the identification of virulence factors involved in pathogenesis and the assessment of their potential values in the control and prevention of leptospirosis.

Author List

Evangelista KV, Coburn J

Author

Jenifer Coburn PhD Professor in the Medicine department at Medical College of Wisconsin




Scopus

2-s2.0-77957582069   155 Citations

MESH terms used to index this publication - Major topics in bold

Acute Disease
Animals
Chronic Disease
Communicable Diseases, Emerging
Cricetinae
Disease Models, Animal
Dogs
Guinea Pigs
Host-Pathogen Interactions
Humans
Leptospira
Leptospirosis
Mice
Rats
Virulence
jenkins-FCD Prod-331 a335b1a6d1e9c32173c9534e6f6ff51494143916