Faculty Collaboration Database

Effects of desflurane, sevoflurane and halothane on postinfarction spontaneous dysrhythmias in dogs. Acta Anaesthesiol Scand 1998 Mar;42(3):353-7

Date

05/23/1998

Pubmed ID

9542565

DOI

10.1111/j.1399-6576.1998.tb04929.x

Scopus ID

2-s2.0-0031889430 (requires institutional sign-in at Scopus site)   19 Citations

Abstract

BACKGROUND: Although desflurane (DES) and sevoflurane (SEV) have desirable features for use in patients with coronary artery disease, their effects on ventricular dysrhythmias following infarction are less known. We therefore examined the effects of DES and SEV upon spontaneous postinfarction ventricular dysrhythmias in dogs, and compared those effects to the well-established antidysrhythmic effects of halothane (HAL) in this model.

METHODS: After institutional approval, the left anterior descending coronary artery was ligated in 16 adult mongrel dogs during isoflurane anesthesia. All dogs developed acute myocardial infarction and severe ventricular tachydysrhythmias. Twenty-two hours after infarction, dogs were anesthetized at 1.5 MAC with desflurane (10.8%) followed by sevoflurane (3.5%) in the treatment group (n = 10), or halothane (1.3%) in the other group (n = 6). Anesthetic gases were allowed to equilibrate for at least 20 min at each end-tidal concentration. At this time, the ECG was recorded for 9 min and evaluated for the number of ventricular ectopic and sinoatrial beats and summed duration of ventricular tachycardia.

RESULTS: DES and SEV reduced the average rate of total ventricular ectopic beats by 40 +/- 4% and 42 +/- 4%, respectively. HAL decreased total ventricular ectopic rate by 59 +/- 6% and 62 +/- 5% after durations of anesthesia comparable to DES and SEV, respectively. Decreases in dysrhythmia in the presence of DES and SEV were significantly smaller than those produced by HAL after a comparable total duration of anesthesia.

CONCLUSION: DES and SEV inhibit spontaneous postinfarction ventricular dysrhythmias, although attenuation of dysrhythmias was smaller than the inhibition during comparable doses of HAL.

Author List

Novalija E, Hogan QH, Kulier AH, Turner LH, Bosnjak ZJ

Author

Quinn H. Hogan MD Professor in the Anesthesiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Anesthesia, Inhalation
Anesthetics, Inhalation
Animals
Arrhythmias, Cardiac
Dogs
Electrocardiography
Halothane
Heart Rate
Isoflurane
Methyl Ethers
Myocardial Infarction