Faculty Collaboration Database

Pathway-based genome-wide association analysis identified the importance of EphrinA-EphR pathway for femoral neck bone geometry. Bone 2010 Jan;46(1):129-36

Date

09/30/2009

Pubmed ID

19786129

Pubmed Central ID

PMC2818219

DOI

10.1016/j.bone.2009.09.025

Scopus ID

2-s2.0-72149108138 (requires institutional sign-in at Scopus site)   20 Citations

Abstract

Femoral neck (FN) bone geometry is an important predictor of bone strength with high heritability. Previous studies have revealed certain candidate genes for FN bone geometry. However, the majority of the underlying genetic factors remain to be discovered. In this study, pathway-based genome-wide association analysis was performed to explore the joint effects of genes within biological pathways on FN bone geometry variations in a cohort of 1000 unrelated US whites. Nominal significant associations (nominal p value<0.05) were observed between 76 pathways and a key FN bone geometry variable-section modulus (Z), biomechanically indicative of bone strength subject to bending. Among them, EphrinA-EphR pathway was most significantly associated with FN Z even after multiple testing adjustments (p(FWER) value=0.035). The association of EphrinA-EphR pathway with FN Z was also observed in an independent sample from Framingham Osteoporosis Study. Overall, these results suggest the significant genetic contribution of EphrinA-EphR pathway to femoral neck bone geometry.

Author List

Chen Y, Xiong DH, Guo YF, Pan F, Zhou Q, Zhang F, Deng HW

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Ephrins
Female
Femur Neck
Genome-Wide Association Study
Genotype
Humans
Male
Middle Aged
Signal Transduction