Medical College of Wisconsin
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Related donor bone marrow transplantation for chronic myelogenous leukemia. Hematol Oncol Clin North Am 1998 Feb;12(1):81-92 PMID: 9523226

Pubmed ID

9523226

Abstract

HLA-identical sibling bone marrow transplantation is an effective and commonly used therapy for young patients with chronic myelogenous leukemia. Efficacy results from high dose chemotherapy, with or without radiation, given for pretransplant conditioning and from immune-mediated antileukemia effects of the graft. The primary determinant of outcome is the patient's disease phase at time of transplant, with best results observed when transplants are done early in the chronic phase. Major causes of treatment failure are graft-versus-host disease and other transplant-related complications. Relatively few patients relapse unless the disease is advanced pretransplant or the donor bone marrow is T-cell depleted.

Author List

Passweg JR, Rowlings PA, Horowitz MM

Author

Mary M. Horowitz MD, MS Center Director, Professor in the Medicine department at Medical College of Wisconsin




Scopus

2-s2.0-0031910352   8 Citations

MESH terms used to index this publication - Major topics in bold

Bone Marrow Transplantation
HLA Antigens
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Tissue Donors
Transplantation, Homologous
Treatment Outcome
jenkins-FCD Prod-297 dff1a717c492f00bf6291286365f1f4fe95208f1