Diabetes abolishes ischemic preconditioning: role of glucose, insulin, and osmolality. Am J Physiol Heart Circ Physiol 2000 Apr;278(4):H1218-24
Date
04/06/2000Pubmed ID
10749717DOI
10.1152/ajpheart.2000.278.4.H1218Scopus ID
2-s2.0-0034058814 (requires institutional sign-in at Scopus site) 198 CitationsAbstract
Recent evidence indicates that hyperglycemia is an important risk factor for the development of cardiovascular disease. We tested the hypothesis that myocardial infarct size is related to blood glucose concentration in the presence or absence of ischemic preconditioning (PC) stimuli in canine models of diabetes mellitus and acute hyperglycemia. Barbiturate-anesthetized dogs were subjected to a 60-min period of coronary artery occlusion and 3-h reperfusion. Infarct size was 24 +/- 2% of the area at risk (AAR) for infarction in control dogs. PC significantly (P < 0.05) decreased the extent of infarction in normal (8 +/- 2% of AAR), but not diabetic (22 +/- 4% of AAR), dogs. Infarct size was linearly related to blood glucose concentration during acute hyperglycemia (r = 0.96; P < 0.001) and during diabetes (r = 0.74; P < 0.002) in the presence or absence of PC stimuli. Increases in serum osmolality caused by administration of raffinose (300 g) did not increase infarct size (11 +/- 3% of AAR) or interfere with the ability of PC to protect against infarction (2 +/- 1% of AAR). The results indicate that hyperglycemia is a major determinant of the extent of myocardial infarction in the dog.
Author List
Kersten JR, Toller WG, Gross ER, Pagel PS, Warltier DCAuthor
Paul S. Pagel MD, PhD Professor in the Anesthesiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBlood Glucose
Blood Pressure
Coronary Circulation
Diabetes Mellitus, Experimental
Dogs
Heart Rate
Hyperglycemia
Insulin
Ischemic Preconditioning
Myocardial Infarction
Myocardial Ischemia
Osmolar Concentration
Raffinose