Faculty Collaboration Database

Comparative genomics of trypanosomatid parasitic protozoa. Science 2005 Jul 15;309(5733):404-9

Date

07/16/2005

Pubmed ID

16020724

DOI

10.1126/science.1112181

Scopus ID

2-s2.0-22244472295 (requires institutional sign-in at Scopus site)   656 Citations

Abstract

A comparison of gene content and genome architecture of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major, three related pathogens with different life cycles and disease pathology, revealed a conserved core proteome of about 6200 genes in large syntenic polycistronic gene clusters. Many species-specific genes, especially large surface antigen families, occur at nonsyntenic chromosome-internal and subtelomeric regions. Retroelements, structural RNAs, and gene family expansion are often associated with syntenic discontinuities that-along with gene divergence, acquisition and loss, and rearrangement within the syntenic regions-have shaped the genomes of each parasite. Contrary to recent reports, our analyses reveal no evidence that these species are descended from an ancestor that contained a photosynthetic endosymbiont.

Author List

El-Sayed NM, Myler PJ, Blandin G, Berriman M, Crabtree J, Aggarwal G, Caler E, Renauld H, Worthey EA, Hertz-Fowler C, Ghedin E, Peacock C, Bartholomeu DC, Haas BJ, Tran AN, Wortman JR, Alsmark UC, Angiuoli S, Anupama A, Badger J, Bringaud F, Cadag E, Carlton JM, Cerqueira GC, Creasy T, Delcher AL, Djikeng A, Embley TM, Hauser C, Ivens AC, Kummerfeld SK, Pereira-Leal JB, Nilsson D, Peterson J, Salzberg SL, Shallom J, Silva JC, Sundaram J, Westenberger S, White O, Melville SE, Donelson JE, Andersson B, Stuart KD, Hall N

MESH terms used to index this publication - Major topics in bold

Animals
Biological Evolution
Chromosomes
Evolution, Molecular
Gene Transfer, Horizontal
Genes, Protozoan
Genome, Protozoan
Genomics
Leishmania major
Molecular Sequence Data
Multigene Family
Mutation
Phylogeny
Plastids
Proteome
Protozoan Proteins
Recombination, Genetic
Retroelements
Species Specificity
Symbiosis
Synteny
Telomere
Trypanosoma brucei brucei
Trypanosoma cruzi