Faculty Collaboration Database

New target regions for human hypertension via comparative genomics. Genome Res 2000 Apr;10(4):473-82

Date

04/26/2000

Pubmed ID

10779487

Pubmed Central ID

PMC310887

DOI

10.1101/gr.10.4.473

Scopus ID

2-s2.0-0034098728 (requires institutional sign-in at Scopus site)   199 Citations

Abstract

Models of human disease have long been used to understand the basic pathophysiology of disease and to facilitate the discovery of new therapeutics. However, as long as models have been used there have been debates about the utility of these models and their ability to mimic clinical disease at the phenotypic level. The application of genetic studies to both humans and model systems allows for a new paradigm, whereby a novel comparative genomics strategy combined with phenotypic correlates can be used to bridge between clinical relevance and model utility. This study presents a comparative genomic map for "candidate hypertension loci in humans" based on translating QTLs between rat and human, predicting 26 chromosomal regions in the human genome that are very likely to harbor hypertension genes. The predictive power appears robust, as several of these regions have also been implicated in mouse, suggesting that these regions represent primary targets for the development of SNPs for linkage disequilibrium testing in humans and/or provide a means to select specific models for additional functional studies and the development of new therapeutics.

Author List

Stoll M, Kwitek-Black AE, Cowley AW Jr, Harris EL, Harrap SB, Krieger JE, Printz MP, Provoost AP, Sassard J, Jacob HJ

Authors

Allen W. Cowley Jr PhD Professor in the Physiology department at Medical College of Wisconsin
Anne E. Kwitek PhD Professor in the Physiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Genome, Human
Humans
Hypertension
Likelihood Functions
Linkage Disequilibrium
Mice
Predictive Value of Tests
Quantitative Trait, Heritable
Rats
Rats, Inbred ACI
Rats, Inbred BN
Rats, Inbred Dahl
Rats, Inbred SHR
Rats, Inbred WKY