Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Fungal allergens and peptide epitopes. Peptides 2000 Apr;21(4):589-99 PMID: 10822116

Abstract

Fungal allergens represent a major cause of atopic disorders. Immunochemical and molecular characterization of fungal allergens has been hampered by the lack of pure proteins and to inherent variation among fungal proteins and in their poor yields. With the advent of molecular biology techniques, a number of allergens have been cloned, sequenced, and expressed from a variety of fungal species. The knowledge of the primary, secondary, and tertiary structures of these allergens, the immunodominant regions of these proteins, and their interaction with T and B-cell epitopes, results in better understanding of the molecular mechanisms of allergy and may provide avenues of immunologic intervention to treat patients. The present review deals with the current understanding of fungal allergen epitopes.

Author List

Kurup VP, Banerjee B

Author

Banani Banerjee PhD Associate Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Allergens
Antigens, Fungal
Epitopes, B-Lymphocyte
Epitopes, T-Lymphocyte
Fungal Proteins
Fungi



View this publication's entry at the Pubmed website PMID: 10822116
jenkins-FCD Prod-141 f776ee82366dc5656a368d51cce32734d2f9b9a0