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Detecting changes in human cerebral blood flow after acute exercise using arterial spin labeling: implications for fMRI. J Neurosci Methods 2010 Aug 30;191(2):258-62 PMID: 20603148

Pubmed ID

20603148

Abstract

The use of arterial spin labeling to measure cerebral blood flow (CBF) after acute exercise has not been reported. The aims of this study were to examine: (1) the optimal inversion time to detect changes in CBF after acute exercise and (2) if acute exercise alters CBF in the motor cortex at rest or during finger-tapping. Subjects (n=5) performed 30 min of moderate intensity exercise on an electronically braked cycle ergometer (perceived exertion 'somewhat hard'). Before and after exercise, relative CBF was measured using multiple inversion time (TI) pulsed arterial spin labeling (PASL). Two multiple TI runs were obtained at rest and during 4 Hz finger-tapping. Four inversion times (675, 975, 1275, and 1,575 ms) were acquired per run, with 20 interleaved pairs of tag and control images per inversion time (320 s run). The results indicated that global CBF increased approximately 20% following exercise, with significant differences observed at an inversion time of 1,575 ms (p<.05). Finger-tapping induced CBF in the motor cortex significantly increased from before to after exercise at TI=1,575 ms (p<.01). These findings suggest changes in human cerebral blood flow that result from acute moderate intensity exercise can be detected afterwards using PASL at 3T with an inversion time of 1,575 ms. The effect of prior acute exercise to increase motor cortex CBF during the performance of a motor task suggests future use of indices of functional activation should account for exercise-induced changes in cardio-pulmonary physiology and CBF.

Author List

Smith JC, Paulson ES, Cook DB, Verber MD, Tian Q

Author

Eric Paulson PhD Associate Professor in the Radiation Oncology department at Medical College of Wisconsin




Scopus

2-s2.0-77955769204   33 Citations

MESH terms used to index this publication - Major topics in bold

Adult
Brain Mapping
Cerebral Arteries
Cerebrovascular Circulation
Exercise
Female
Humans
Magnetic Resonance Imaging
Male
Monitoring, Physiologic
Motor Cortex
Physical Fitness
Spin Labels
Young Adult
jenkins-FCD Prod-296 4db9d02597e0a2e889e230f853b641c12f1c3ee3