Faculty Collaboration Database

DNA binding of 4,4'-methylene-bis(2-chloroaniline) (MOCA) in explant cultures of human and dog bladder. Cancer Lett 1987 Dec;38(1-2):41-8

Date

12/01/1987

Pubmed ID

3690513

DOI

10.1016/0304-3835(87)90198-4

Scopus ID

2-s2.0-0023520947 (requires institutional sign-in at Scopus site)   10 Citations

Abstract

The binding to DNA of 4,4'-methylene-bis(2-chloroaniline) (MOCA) in explant cultures of human and dog bladder was compared. The DNA binding of MOCA in both human and dog bladder explants increased with the concentration of MOCA in the medium. In both species, there appeared to be a population with high DNA binding activity and another with low DNA binding activity. Furthermore, the binding of MOCA to human bladder DNA appeared to be higher than to dog bladder DNA. The results indicate the potential of MOCA to induce genetic damage in human bladder and suggest caution in the occupational exposure of humans to this chemical.

Author List

Shivapurkar N, Lehman TA, Schut HA, Stoner GD

MESH terms used to index this publication - Major topics in bold

Animals
Benzhydryl Compounds
DNA
Dogs
Humans
Leucine
Methylenebis(chloroaniline)
Organ Culture Techniques
Species Specificity
Thymidine
Urinary Bladder
Urinary Bladder Neoplasms