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Immunoglobulin allotypes among the Bicolanos of Sorsogon province, Luzon, Philippines: implications of phenotypes for filariasis. Exp Clin Immunogenet 1999;16(2):65-71

Date

05/27/1999

Pubmed ID

10343157

DOI

10.1159/000019097

Abstract

Immunoglobulin (Ig) allotypes are polymorphic genetic systems that show distinct racial arrays, thus making them powerful tools for studies of genetic admixture and biological relationships. In the province of Sorsogon, southern Luzon, Philippines, allotyping was completed on 252 persons residing in two neighboring villages. The people demonstrated 14 GM and 3 KM phenotypes. The frequency of homozygous KM3, KM1 and heterozygous KM1,3 was identical in these villages; however, half of the GM phenotypes present in one village were significantly less frequent in the other village. The frequency of KM and GM haplotypes was different from those reported in Filipino aboriginal groups, but similar to a population on Samar Island, the only other Filipino group for which Ig allotype data exist. Variability in the prevalence of parasitic disease such as lymphatic filariasis may in part reflect differences in genetic susceptibility, resulting from allotypic heterogeneity between villages.

Author List

Kron MA, Ramirez B, Belizario V Jr, Pandey JP

Author

Michael Kron MD Director, Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Asian Continental Ancestry Group
Elephantiasis, Filarial
Haplotypes
Humans
Immunoglobulin Allotypes
Immunoglobulin Gm Allotypes
Phenotype
Philippines
Prevalence
jenkins-FCD Prod-388 89e904233d719332173309c68ab82b0b2a78a3a7