Searching for obesity genes: progress and prospects. Drugs Today (Barc) 2005 May;41(5):345-62
Date
08/06/2005Pubmed ID
16082432DOI
10.1358/dot.2005.41.5.893615Scopus ID
2-s2.0-23044456626 (requires institutional sign-in at Scopus site) 11 CitationsAbstract
Obesity is a condition of excess body fat that causes or exacerbates several major public health problems. Remarkable progress has been made in the molecular elucidation of monogenic forms of obesity both in rodents and in humans. The most common form of obesity, however, is considered to be a polygenic disorder arising from the interaction of multiple genetic and environmental factors. Identification and characterization of susceptibility genes underlying obesity will contribute to a greater understanding of the pathogenesis of obesity and ultimately will assist in the development of better strategies for prevention and therapeutic intervention. In this article, we discuss the current status and future perspectives for the genetic dissection of obesity, with a focus on the most striking or representative findings.
Author List
Liu YJ, Xiao P, Xiong DH, Recker RR, Deng HWMESH terms used to index this publication - Major topics in bold
AnimalsChromosome Mapping
Disease Models, Animal
Genetic Heterogeneity
Genetic Linkage
Genetic Predisposition to Disease
Genetic Therapy
Humans
Mutation
Obesity
PPAR gamma
Receptors, Adrenergic, beta-3
Receptors, Cell Surface
Receptors, Leptin
