Chemoprevention of lung squamous cell carcinoma in mice by a mixture of Chinese herbs. Cancer Prev Res (Phila) 2009 Jul;2(7):634-40
Date
07/09/2009Pubmed ID
19584077Pubmed Central ID
PMC3890236DOI
10.1158/1940-6207.CAPR-09-0052Scopus ID
2-s2.0-69249162699 (requires institutional sign-in at Scopus site) 41 CitationsAbstract
Antitumor B (ATB) is a Chinese herbal mixture of six plants. Previous studies have shown significant chemopreventive efficacy of ATB against human esophageal and lung cancers. We have recently developed a new mouse model for lung squamous cell carcinomas (SCC). In this study, lung SCC mouse model was characterized using small-animal imaging techniques (magnetic resonance imaging and computed tomography). ATB decreased lung SCC significantly (3.1-fold; P < 0.05) and increased lung hyperplastic lesions by 2.4-fold (P < 0.05). This observation suggests that ATB can block hyperplasia from progression to SCC. ATB tissue distribution was determined using matrine as a marker chemical. We found that ATB is rapidly absorbed and then distributes to various tissues including the lung. These results indicate that ATB is a potent chemopreventive agent against the development of mouse lung SCCs.
Author List
Wang Y, Zhang Z, Garbow JR, Rowland DJ, Lubet RA, Sit D, Law F, You MMESH terms used to index this publication - Major topics in bold
AnimalsAnticarcinogenic Agents
Biological Assay
Carcinoma, Squamous Cell
Chemoprevention
Disease Models, Animal
Drugs, Chinese Herbal
Female
Humans
Lung
Lung Neoplasms
Magnetic Resonance Imaging
Mice
X-Ray Microtomography
