Medical College of Wisconsin
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Bone marrow transplants may cure patients with acute leukemia never achieving remission with chemotherapy. Blood 1992 Aug 15;80(4):1090-3 PMID: 1498326

Pubmed ID



About 30% of adults with acute lymphoblastic leukemia (ALL) and 20% to 40% of children and adults with acute myelogenous leukemia (AML) never achieve remission, even with intensive chemotherapy. Most die of resistant leukemia, often within 6 months or less. In this study of 126 patients with resistant ALL or AML, allogeneic bone marrow transplants from HLA-identical siblings produced remissions in 113 of 115 (98%) evaluable patients. The 3-year probability of leukemia-free survival was 21% (95% confidence interval, 15% to 29%). Leukemia-free survival was similar in ALL (23%, 12% to 40%) and AML (21%, 14% to 31%). Only 3 of 27 patients at risk relapsed more than 2 years posttransplant.

Author List

Biggs JC, Horowitz MM, Gale RP, Ash RC, Atkinson K, Helbig W, Jacobsen N, Phillips GL, Rimm AA, Ringdén O


Mary M. Horowitz MD, MS Center Director, Professor in the Medicine department at Medical College of Wisconsin


2-s2.0-0026754295   165 Citations

MESH terms used to index this publication - Major topics in bold

Bone Marrow Transplantation
Child, Preschool
Drug Resistance
Graft vs Host Disease
Leukemia, Myeloid, Acute
Middle Aged
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Remission Induction
Survival Rate
jenkins-FCD Prod-331 a335b1a6d1e9c32173c9534e6f6ff51494143916